anti-CD40 (mouse), mAb (FGK45) (preservative free)

Product description: CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

Alternate Names/Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 5; CD40L Receptor

Product Type: Monoclonal Antibody

Clone: FGK45

Isotype: Rat IgG2a

Immunogen: Recombinant mouse CD40 fusion protein.

Applications: FACS, FUNC

Species Crossreactivity: Mouse

Specificity: Recognizes mouse CD40.

Endotoxin: <0.1EU/µg purified protein (LAL test; Lonza).

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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