anti-CD40L (human), mAb (rec.) (blocking) (hu5c8) (preservative free)

Product description: CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.

Alternate Names/Synonyms: CD40 Ligand; CD154; Tumor Necrosis Factor Ligand Superfamily Member 5;TNFSF5; Gp39; TRAP

Product Type: Recombinant Antibody

Clone: hu5c8

Isotype: Human IgG1kappa

Immunogen: Recombinant human CD40L.

Labels - Conjugates: Preservative Free

Applications: FACS, FUNC, FUNC (Blocking), WB

Species Crossreactivity: Dog, Human

Specificity: Recognizes and binds human CD40L with an IC50 of 0.845µg/ml. Cross-reacts with canine CD40L.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.

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