anti-CD47 (human), mAb (ANC2F6) (Biotin)

Product description: Human CD47 (IAP; Integrin Associated Protein) is a broadly expressed Ig superfamily glycoprotein of about 50kD with a long extracellular Ig like domain, 5 transmembrane domains and an alternatively spliced intracellular C-terminal domain. It interacts with its ligand SIRPalpha (CD172a; Signal Regulatory Protein) expressed mainly on myeloid cells serving as a negative immune regulator, inhibiting phagocytosis. The CD47-SIRPalpha axis is being investigated as possible anti-tumor immune intervention point. Blockade of this interaction has shown promise in models of HNSCC, glioma and breast cancer.

Alternate Names/Synonyms: IAP; Integrin Associated Protein; Leukocyte Surface Antigen CD47

Product Type: Monoclonal Antibody

Clone: ANC2F6

Isotype: Mouse IgG1kappa

Immunogen: Recombinant human CD47 (extracellular Ig domain).

Labels - Conjugates: Biotin

Applications: ELISA, FACS

Species Crossreactivity: Human

Specificity: Binds to an epitope within the extracellular Ig-like domain of human CD47.

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at +4°C.

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