anti-CD5 (human), Rabbit Monoclonal (RM354)

Product description: CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome. CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3.

Alternate Names/Synonyms: T-cell Surface Glycoprotein CD5; Lymphocyte Antigen T1/Leu-1

Product Type: Recombinant Antibody

Clone: RM354

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the N-terminus (extracellular domain) of human T-cell surface glycoprotein CD5.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human CD5 .

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Lien vers la Fiche Technique