anti-CLDN 18.2, Rabbit Monoclonal (RM510)

Product description: Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lungs. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung-specific. CLDN18.2 is maintained during the course of malignant transformation and is thus frequently displayed on the surface of human gastric cancer cells.

Alternate Names/Synonyms: Claudin-18 Isoform A2

Product Type: Recombinant Antibody

Clone: RM510

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues of human Claudin-18 Isoform A2.

Applications: IHC

Species Crossreactivity: Human, Mouse, Rat

Specificity: This antibody reacts to human CLDN18.2 (Claudin 18.2) (Isoform A2 of Claudin-18). This antibody may also react to mouse or rat CLDN18.2, as predicted by immunogen homology.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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