anti-Cyclin B1 (human), Rabbit Monoclonal (RM281)

Product description: Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC-dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate and non-small cell lung cancer.

Alternate Names/Synonyms: CCNB1; G2/Mitotic-specific Cyclin-B1

Product Type: Recombinant Antibody

Clone: RM281

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to Cyclin B1.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human Cyclin B1.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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