anti-Delta2 alpha-Tubulin (dC2-alpha-Tubulin), Rabbit Monoclonal (RM447)

Product description: Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule diversity: the expression of different alpha- and beta-tubulin genes, referred to as tubulin isotypes, and the generation of posttranslational modifications (PTMs) on alpha- and beta-tubulin. Tubulin PTMs include the well-known acetylation or phosphorylation, and others that have so far mostly been found on tubulin, detyrosination/tyrosination, polyglutamylation and polyglycylation. These PTMs might have evolved to specifically regulate tubulin and microtubule functions. Detyrosination is a form of posttranslational modification that occurs on alpha-tubulin. It consists of the removal of the C-terminal tyrosine to expose a glutamate at the newly formed C-terminus. Tubulin polymers, called microtubules, that contain detyrosinated alpha-tubulin are usually referred to as Glu-microtubules while unmodified polymers are called Tyr-microtubules.

Alternate Names/Synonyms: dC2 alpha-Tubulin

Product Type: Recombinant Antibody

Clone: RM447

Isotype: Rabbit IgG

Immunogen: A peptide corresponding corresponding to dC2-alpha-Tubulin.

Applications: ICC, WB, IF

Species Crossreactivity: Human

Specificity: This antibody reacts to Delta2 alpha-Tubulin (dC2-alpha-tubulin), a C-terminally trimmed version of alpha-tubulin that lacks a carboxy-terminal glutamyl-tyrosine group.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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