anti-Desmin, Rabbit Monoclonal (RM234)

Product description: Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue. Desmin (DES) mutations have been associated with restrictive, dilated, idiopathic, arrhythmogenic and non-compaction cardimyopathy.

Alternate Names/Synonyms: DESM

Product Type: Recombinant Antibody

Clone: RM234

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to human Desmin.

Applications: IHC, WB

Species Crossreactivity: Human, Mouse

Specificity: This antibody reacts to human and mouse Desmin. This antibody may also react to rat and Bovine Desmin, as predicted by immunogen homology.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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