anti-ER alpha (human), Rabbit Monoclonal (RM292)

Product description: Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 Estrogen receptor-alpha (ER-alpha) isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer and osteoporosis.

Alternate Names/Synonyms: Estrogen Receptor

Product Type: Recombinant Antibody

Clone: RM292

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues near the N-terminus of human ER-alpha.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to reacts to human ER-alpha (Estrogen receptor).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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