anti-FADD (human), mAb (1C4)

Product description: FADD (FAS-associated death domain protein) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. FADD is also involved in interferon-mediated antiviral immune response and functions in the positive regulation of interferon signaling. FADD also plays a role in embryonic development and the cell cycle reentry of T cells.

Alternate Names/Synonyms: FAS-associated Death Domain Protein; Growth-inhibiting Gene 3 Protein; Mediator of Receptor Induced Toxicity; MORT1

Product Type: Monoclonal Antibody

Clone: 1C4

Isotype: Mouse IgG1

Immunogen: Recombinant human FADD.

Applications: ELISA, IP, WB

Species Crossreactivity: Human

Specificity: Recognizes the C-terminus of human FADD only in its unphosphorylated form.

Concentration: 1 mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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