anti-FAK (Focal adhesion kinase 1), Rabbit Monoclonal (RM472)

Product description: FAK1 (Focal Adhesion Kinase 1) is a non-receptor protein tyrosine kinase that is involved in the regulation of cell adhesion, migration, and survival. It is a member of the Src family of kinases. FAK1 is activated by binding to integrins, which are transmembrane proteins that mediate the attachment of cells to the extracellular matrix. When FAK1 is activated, it phosphorylates a number of downstream targets, including paxillin, tensin, and the small GTPase Ras. These phosphorylation events lead to the activation of a number of signaling pathways, including the MAPK pathway, the PI3K-AKT pathway, and the NF-kappaB pathway. The MAPK pathway is involved in the regulation of cell migration, survival, and proliferation. The PI3K-AKT pathway is involved in the regulation of cell survival and metabolism. The NF-kappaB pathway is involved in the regulation of inflammation and immunity.

Alternate Names/Synonyms: Focal Adhesion Kinase 1; Protein-tyrosine Kinase 2; PTK2

Product Type: Recombinant Antibody

Clone: RM472

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues surrounding Tyr397 of human FAK1 (Focal adhesion kinase 1).

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: RM472 reacts to human FAK (Focal adhesion kinase 1). This antibody may also react to mouse or rat FAK, as predicted by immunogen homology.

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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