anti-Fas (human), mAb (APO-1-3) (preservative free)

Product description: Fas (CD95) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. The formation of the Fas death-inducing signaling complex (DISC) is the initial step of Fas signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. Stimulation of Fas has been also reported to trigger non-apoptotic pathways. It has been shown that membrane-bound FasL is essential for the cytotoxic activity, whereas soluble FasL appears to promote autoimmunity and tumorigenesis via induction of non-apoptotic pathways, in particular NF-kappaB.

Alternate Names/Synonyms: CD95; APO-1; TNFRSF6; Tumor Necrosis Factor Receptor Superfamily Member 6; Apoptosis-mediating Surface Antigen FAS

Product Type: Monoclonal Antibody

Clone: APO-1-3

Isotype: Mouse IgG3

Immunogen: Recombinant human Fas.

Labels - Conjugates: Preservative Free

Applications: FACS, FUNC, IP, WB

Species Crossreactivity: Human

Specificity: Recognizes human Fas.

Concentration: 1 mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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