anti-FLIP, mAb (Dave-2)

Product description: FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.

Alternate Names/Synonyms: I-FLICE; CLARP; CASPER; Usurpin, CASH; FLAME-1

Product Type: Monoclonal Antibody

Clone: Dave-2

Isotype: Rat IgG2a

Immunogen: Recombinant human FLIP (aa 1-480).

Applications: IP, WB

Species Crossreactivity: Human, Mouse

Specificity: Recognizes an epitope (aa 1-200) present in both short (FLIPS) and long (FLIPL) splice variants of human and mouse FLIP.

Endotoxin: <0.001EU/µg purified protein or <1EU/mg purified protein (LAL test; Lonza).

Concentration: 1 mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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