anti-GATA3, Rabbit Monoclonal (RM482)

Product description: GATA3 functions as a major regulator of T helper 2 (Th2) cell differentiation in immune cells. GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediated pathway, which results in production of IL-4, IL-5, and IL-13 cytokines, responsible for preferential differentiation of Th2-cells. GATA3 has been shown to regulate early developmental processes of T cells, such as T cell commitment, positive selection, and post-commitment CD4+ T cell survival. GATA3 coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL-33. Upon tissue injury, acts downstream of IL-33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. GATA3 has been reported to be essential in the development of a variety of normal tissues. Defect in GATA3 results in hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR syndrome).

Alternate Names/Synonyms: Trans-acting T-cell-specific Transcription Factor GATA-3; GATA-Binding Factor 3

Product Type: Recombinant Antibody

Clone: RM482

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to human GATA3.

Applications: IHC, WB

Species Crossreactivity: Human, Mouse, Rat

Specificity: This antibody reacts to human GATA3 and may also react to mouse or rat GATA3, as predicted by immunogen homology.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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