anti-GLUT2 (rat), pAb (IN119)

Product description: GLUT2 belongs to the family of glucose transporters (GLUTs, encoded by the SLC2A genes), which comprises 14 isoforms. GLUT2 has a uniquely low affinity for glucose (Km ~ 17mmol/l), and can also use mannose, galactose and fructose as low-affinity substrates. However, it has a high affinity for glucosamine (Km ~ 0.8mmol/l). GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. GLUT2 is also the major glucose transporter in the plasma membrane of hepatocytes. In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. In the nervous system, GLUT2-dependent glucose-sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities.

Alternate Names/Synonyms: Solute Carrier Family 2, Facilitated Glucose Transporter Member 2; SLC2A2; Glucose Transporter Type 2, Liver

Product Type: Polyclonal Antibody

Immunogen: A synthetic peptide corresponding to 10 aa located near the C-terminus of rat GLUT2.

Applications: IHC, IP, WB

Species Crossreactivity: Rat

Specificity: Recognizes rat GLUT2.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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