anti-Granzyme B (human), Rabbit Monoclonal (RM441)

Product description: Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. Shown to activate caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis

Alternate Names/Synonyms: CGL1; Cathepsin G-like 1; CTLA-1; Fragmentin-2

Product Type: Recombinant Antibody

Clone: RM441

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human Granzyme B.

Applications: IHC

Species Crossreactivity: Human

Specificity: This antibody reacts to human Granzyme B.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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