anti-GST3/GST pi (human), Rabbit Monoclonal (RM347)

Product description: Inhibition of free radicals and the damage they produce is critical for cell survival, particularly in neurons. Glutathione S-transferases (GSTs) are a class of inducible, multifunctional, detoxifying enzymes that catalyze the reduction of hydrophobic electrophiles, like those generated by pesticides and chemotherapeutic compounds. In mammals, six different isoforms alpha, mu, pi, theta, omega, and zeta have been identified. GST-Pi is expressed in many human tissues, particularly in the biliary tree, renal distal convoluted tubules and lungs. GST-Pi overexpression has been observed in many tumors compared with the surrounding normal tissues and in various cancer cell lines resistant to anticancer agents. It has been shown that GST-Pi acts as a regulator of mitogen-activated protein (MAP) kinases. GST-Pi is an endogenous inhibitor of c-Jun NH2-terminal kinase (JNK), mediated by interactions with the NH2-terminal region of the kinase. After oxidative stress, GST-Pi oligomerizes and disassociates from JNK, which then becomes phosphorylated. GST-Pi can also modulate the activation of p38 and extracellular signal-regulated kinase (ERK).

Alternate Names/Synonyms: Glutathione S-transferase P; GST pi; GSTP1-1

Product Type: Recombinant Antibody

Clone: RM347

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human GST3/GST-pi.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human GST3/GST-pi (Glutathione S-transferase P).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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