anti-HDAC3 (human), Rabbit Monoclonal (RM439)

Product description: HDAC3 is a histone deacetylase and is responsible for the deacetylation of lysine residues on core histones and other histone substrates. The deacetylation of histones is important for transcriptional regulation, cell cycle progression and other developmental related functions. HDAC3 represses gene expression by participating in the transcriptional repressor activity of BCL6, by deacetylating H3K27 on enhancer elements. It is also thought to participate in transcriptional regulation through binding to YY1, a zinc-finger transcription factor. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. The HDAC3 gene is regarded as a potential tumor suppressor gene.

Alternate Names/Synonyms: Histone Deacetylase 3; RPD3-2; SMAP45

Product Type: Recombinant Antibody

Clone: RM439

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of HDAC3.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human HDAC3.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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