anti-Histone H2AZ, Rabbit Monoclonal (RM215)

Product description: Histones are proteins that package DNA into nucleosomes. Histones are responsible for maintaining the shape and structure of a nucleosome. One chromatin molecule is composed of at least one of each core histones per 100 base pairs of DNA. There are five families of histones known to date; these histones are termed H1/H5, H2A, H2B, H3, and H4. H2A is considered a core histone, along with H2B, H3 and H4. Core formation first occurs through the interaction of two H2A molecules. Then, H2A forms a dimer with H2B; the core molecule is complete when H3-H4 also attaches to form a tetramer. Histone H2A is composed of non-allelic variants, including H2A.1, H2A.2, H2A.X, and H2A.Z. H2A packages DNA molecules into chromatin and has been correlated with DNA modification and epigenetics. H2A plays a major role in determining the overall structure of chromatin and regulates gene expression. Protein modification on histone H2A exist and can sometimes result in a change in function. Different H2A variants were exploited to have different functions, genetic sequences and modifications.

Alternate Names/Synonyms: H2AZ

Product Type: Recombinant Antibody

Clone: RM215

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human Histone H2AZ.

Applications: ELISA, ICC, WB, Multiplex

Species Crossreactivity: All Vertebrates

Specificity: This antibody reacts to Histone H2AZ protein, independent of post-translational modifications. No cross reactivity with other histone proteins.

Concentration: 1 mg/ml

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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