anti-IL-36beta (human), mAb (Jacky-1)

Product description: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Alternate Names/Synonyms: Interleukin-36beta Interleukin-1 Family Member 8; IL-1F8

Product Type: Monoclonal Antibody

Clone: Jacky-1

Isotype: Mouse IgG1kappa

Immunogen: Recombinant human IL-36beta.

Applications: ELISA, WB

Species Crossreactivity: Human

Specificity: Recognizes human IL-36beta. Does not cross-react with mouse IL-36beta and IL-36gamma.

Endotoxin: <0.01EU/µg purified protein (LAL test; Lonza).

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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