anti-IL-38, mAb (Nhat-1)

Product description: IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.

Alternate Names/Synonyms: Interleukin-38; Interleukin-1 Family Member 10; IL-1F10

Product Type: Monoclonal Antibody

Clone: Nhat-1

Isotype: Mouse IgG2bkappa.

Immunogen: Recombinant human IL-38.

Applications: ELISA, WB

Species Crossreactivity: Human, Mouse

Specificity: Recognizes human and mouse IL-38.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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