anti-Integrin beta3 (human), Rabbit Monoclonal (RM382)

Product description: Integrin beta3 (CD61; GPIIIa; ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.

Alternate Names/Synonyms: CD61; Platelet Membrane Glycoprotein IIIa; GP3a

Product Type: Recombinant Antibody

Clone: RM382

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the internal region of human Integrin beta3.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to Human Integrin beta3A / CD61.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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