anti-LAIR1 (human), Rabbit Monoclonal (RM498)

Product description: LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on the cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in the recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. LAIR1 plays a role in immune response homeostasis, and extracellular matrix remodeling and it is overexpressed in many high-grade cancers.

Alternate Names/Synonyms: Leukocyte-associated Immunoglobulin-like Receptor 1; CD305

Product Type: Recombinant Antibody

Clone: RM498

Isotype: Rabbit IgG

Immunogen: Recombinant extracellular domain of human LAIR1.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human LAIR1.

Endotoxin: <0.001EU/µg purified protein (LAL-test; Lonza)

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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