anti-LTbetaR (mouse), mAb (4H8 WH2)

Product description: The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Alternate Names/Synonyms: Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3

Product Type: Monoclonal Antibody

Clone: 4H8 WH2

Isotype: Rat IgG2a

Immunogen: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).

Applications: FACS, FUNC (Blocking)

Species Crossreactivity: Mouse

Specificity: Recognizes mouse LTbetaR.

Endotoxin: <0.001EU/µg purified protein or <1EU/mg purified protein (LAL test; Lonza).

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Lien vers la Fiche Technique