anti-MDA5 (human), mAb (Hely-1)

Product description: RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

Alternate Names/Synonyms: Helicard; Melanoma Differentiation-associated Gene 5

Product Type: Monoclonal Antibody

Clone: Hely-1

Isotype: Mouse IgG1

Immunogen: Recombinant human MDA5 (aa 78-555).

Applications: ELISA, IP, WB

Species Crossreactivity: Human

Specificity: Recognizes human MDA5. Detects a band at ~115-120kDa by Western blot.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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