anti-MPO (human), Rabbit Monoclonal (RM407)

Product description: Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains and two unglycosylated beta chains. Traditionally, myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities such as periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Myeloperoxidase also participates in the initiation and progression of cardiovascular disease and is a promising cardiac markers. Myeloperoxidase possesses potent proinflammatory properties and may contribute directly to tissue injury. Myeloperoxidase is part of the host defense system of polymorphonuclear leukocytes and myeloperoxidase is responsible for microbicidal activity against a wide range of organisms. In stimulated PMN (polymorphonuclear leukocytes), MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Myeloperoxidase immunostaining is important in the diagnosis of myeloid sarcoma, contrasting with the negative staining of lymphomas.

Alternate Names/Synonyms: Myeloperoxidase

Product Type: Recombinant Antibody

Clone: RM407

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the internal region of light chain on MPO. This antibody may also react to mouse or rat MPO, as predicted by immunogen homology.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human to MPO.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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