anti-MUC-17 (Mucin-17) (human), Rabbit Monoclonal (RM517)

Product description: Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC-17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. MUC-17 interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. MUC-17 probably plays a role in maintaining homeostasis on mucosal surfaces. Increased expression of this molecule has been reported in colon cancer.

Alternate Names/Synonyms: Mucin-17; Small Intestinal Mucin-3 (MUC-3)

Product Type: Recombinant Antibody

Clone: RM517

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues near the C-terminus of human Muc17.

Applications: IHC

Species Crossreactivity: Human

Specificity: This antibody reacts to human Muc-17 (Mucin-17).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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