anti-NAIP1/2/5 (mouse), mAb (Naipa-1)

Product description: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.

Alternate Names/Synonyms: Neuronal Apoptosis Inhibitory Protein 1, 2, 5; Baculoviral IAP Repeat-containing Protein 1a, 1b, 1e; Birc 1a, 1b, 1e

Product Type: Monoclonal Antibody

Clone: Naipa-1

Isotype: Mouse IgG2bkappa

Immunogen: Recombinant mouse NAIP5 (BIR2 domain/aa 159-227).

Applications: WB

Species Crossreactivity: Mouse

Specificity: Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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