anti-NF-kappa-B p105/p50 (human), Rabbit Monoclonal (RM299)

Product description: NF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kappaB sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappaB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappaB inhibitor (I-kappaB) family. In a conventional activation pathway, I-kappaB is phosphorylated by I-kappaB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappaB complex which translocates to the nucleus. NF-kappaB heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappaB p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3.

Alternate Names/Synonyms: Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; NF-kappaB

Product Type: Recombinant Antibody

Clone: RM299

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues in human NF-kappa-B p105 subunit and p50 subunit.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human nuclear factor NF-kappa-B p105 subunit and p50 subunit. It may also react to mouse or rat NF-kappa-B p105/p50, as predicted by immunogen homology.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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