anti-NLRP6/NALP6 (human), mAb (Clint-1)

Product description: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

Alternate Names/Synonyms: NACHT-, LRR and PYD Domains-containing Protein 6; Nod-like Receptor Pyrin Domain-containing Protein 6; NLRP6; Angiotensin II/Vasopressin Receptor; PYRIN-containing APAF1-like Protein 5; NALP6

Product Type: Monoclonal Antibody

Clone: Clint-1

Isotype: Mouse IgG1kappa

Immunogen: Recombinant human NLRP6 (NACHT domain).

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: Recognizes human NLRP6.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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