anti-Notch2, mAb (16F11) (Biotin)

Product description: Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.

Alternate Names/Synonyms: Neurogenic Locus Notch Homolog Protein 2; Motch B

Product Type: Monoclonal Antibody

Clone: 16F11

Isotype: Rat IgG1kappa

Immunogen: Recombinant mouse Notch2:Fc (AG-40B-0110).

Labels - Conjugates: Biotin

Applications: FACS

Species Crossreactivity: Human, Mouse

Specificity: Recognizes human and mouse endogenous Notch2 receptor.

Concentration: 0.5mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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