anti-NS5B (HCV), mAb (blocking) (5B-12B7)

Product description: The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.

Alternate Names/Synonyms: Nonstructural Protein 5B

Product Type: Monoclonal Antibody

Clone: 5B-12B7

Isotype: Mouse IgG2a

Immunogen: Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.

Applications: FUNC (Blocking), ICC, IP

Species Crossreactivity: HCV

Specificity: Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392). Does not react with genotype 2.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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