anti-p120-catenin (human), Rabbit Monoclonal (RM353)

Product description: Catenins are proteins associated with complexes that contain cadherin cell adhesion molecules. p120-Catenin (delta-1-catenin) is a member of the p120 Catenin subfamily and is a structural protein involved in neuronal development. It interacts with Actin, Cortactin and Src Kinases to promote neurite elongation or branching, depending upon its phosphorylation state. Like beta-catenin and gamma-catenin, delta-catenins appear to interact with presenilins. These catenin-presenilin interactions can impact cadherin function and regulation of cell-to-cell adhesion. While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-kB transcription factor. p120-Catenin is an efficient tyrosine kinase substrate implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.

Alternate Names/Synonyms: Catenin delta-1; Cadherin-associated Src Substrate

Product Type: Recombinant Antibody

Clone: RM353

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human p120 catenin (Catenin delta-1).

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts human p120 catenin (Catenin delta-1).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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