anti-p42 MAPK (Erk2), Rabbit Monoclonal (RM483)

Product description: Extracellular signal-regulated kinases 1 and 2 (also known as ERK1/2, p44/42, or MAPK3/1) belong to a family of conserved serine/threonine protein kinases known as mitogen-activated protein kinases (MAPKs) that are involved in many cellular programs such as proliferation, differentiation, motility and survival. The ERK1/2 signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors and cytokines. The primary activators of ERK1/2 are MEK1 and MEK2 which activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187 in ERK1 and ERK2, respectively. Several downstream targets of ERK1/2 have been identified, including p90RSK and the transcription factor Elk-1. ERK1/2 are negatively regulated by MAPK phosphatases as well as by chemical inhibitors of MEK. The ERK pathway is disrupted in many types of cancer and thus is an important target for diagnosis and treatment.

Alternate Names/Synonyms: Mitogen-activated Protein Kinase Isoform p42; Extracellular Signal-regulated Kinase 2

Product Type: Recombinant Antibody

Clone: RM483

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human p42-MAPK (Erk2).

Applications: IHC, WB

Species Crossreactivity: Human, Mouse, Rat

Specificity: This antibody reacts to human p42 MAPK (Erk2). This antibody may also react to mouse or rat Erk2 as predicted by immunogen homology.

Endotoxin: <0.001EU/µg

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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