anti-PD-1 (human), mAb (AG-IHC001)

Product description: Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T cell regulators, expressed as a co-receptor on the surface of activated T cells, B cells and macrophages. Several studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to antitumor immunity, as PD-L1 has been shown to induce apoptosis of activated T cells or inhibit activity of cytotoxic T cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B cells and has therefore been considered a more specific and useful diagnostic marker for angioimmunoblastic T cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non-small-cell lung cancer, melanoma and renal-cell cancer. This antibody is intended to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. It has been optimized and validated using the BOND-MAX fully automated IHC&ISH stainer (see Protocol).

Alternate Names/Synonyms: CD279; Programmed Cell Death Protein 1

Product Type: Monoclonal Antibody

Clone: AG-IHC001

Isotype: Mouse IgG2b

Immunogen: Recombinant human PD-1 fused to a His-tag.

Applications: ELISA, IHC

Species Crossreactivity: Human

Specificity: Recognizes human PD-1 (CD279).

Short Term Storage: +4°C

Long Term Storage: +4°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at +4°C.

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