anti-PD-1 (human), Rabbit Monoclonal (RM309)

Product description: Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T cell regulators, expressed as a co-receptor on the surface of activated T cells, B cells and macrophages. Several studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to antitumor immunity, as PD-L1 has been shown to induce apoptosis of activated T cells or inhibit activity of cytotoxic T cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B cells and has therefore been considered a more specific and useful diagnostic marker for angioimmunoblastic T cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non-small-cell lung cancer, melanoma and renal-cell cancer.

Alternate Names/Synonyms: CD279; Programmed Cell Death Protein 1

Product Type: Recombinant Antibody

Clone: RM309

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the N-terminus of human PD-1.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human PD-1 (Programmed cell death protein 1) (CD279).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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