anti-Phospho-Rsk1 (Thr359/Ser363) (human), Rabbit Monoclonal (RM233)

Product description: The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363 and Thr573, are important for kinase activation. RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters. Evidence from animal models suggests that RSK1 is a key regulator of glucose homeostasis and cell size.

Alternate Names/Synonyms: Ribosomal Protein S6 Kinase alpha-1; S6K-alpha-1; MAPKAPK-1a;

Product Type: Recombinant Antibody

Clone: RM233

Isotype: Rabbit IgG

Immunogen: A phospho-peptide corresponding to human phospho-Rsk1 (Thr359/Ser363).

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human RSK1 only when phosphorylated at Thr359/Ser363.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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