anti-PIDD, pAb (AL233)

Product description: PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

Alternate Names/Synonyms: p53-induced Protein with a Death Domain; Leucine-rich Repeat and Death Domain-containing Protein; Lrdd

Product Type: Polyclonal Antibody

Immunogen: Recombinant human PIDD (Death Domain: aa 776-910).

Applications: IHC, IP, WB

Species Crossreactivity: Human, Mouse

Specificity: Recognizes human and the native form of mouse PIDD. Detects bands of ~90kDa (Full Length FL-PIDD) and ~50kDa (cleaved protein) by Western blot.

Concentration: 1 mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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