anti-PLAP (human), Rabbit Monoclonal (RM317)

Product description: Placental Alkaline Phosphatase (PLAP) plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like and liver/bone/kidney. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type). Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.

Alternate Names/Synonyms: Placental Alkaline Phosphatase; Phospholipase A-2-activating Protein

Product Type: Recombinant Antibody

Clone: RM317

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the N-terminus of human PLAP (Placental alkaline phosphatase).

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human PLAP (Placental alkaline phosphatase).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Lien vers la Fiche Technique