anti-PSD-95, Rabbit Monoclonal (RM288)

Product description: PSD-95 is a member of proteins located at a specialized postsynaptic membrane region, called the postsynaptic density (PSD). PSD-95 is the most abundant scaffold protein specifically enriched in the PSD. It contains three PDZ domains, an SH3 domain and a guanylate kinase (GuK)-like domain. Through its PDZ domains, PSD-95 assembles various synaptic components at the PSD including intracellular signaling molecules (e.g. SynGAP and kalirin-7), ion channels (e.g. stargazin/AMPA receptors [AMPARs] and NMDA receptors) and cell adhesion molecules (e.g. neuroligin). PSD-95 plays a primary role in synaptic development and maturation and is regulated by palmitoylation at its N-terminal cysteine residues leading to its postsynaptic targeting. Palmitoylation of PSD-95 is triggered by DHHC2, a plasma membrane-inserted palmitoylating enzyme. Palmitoylated PSD-95 is almost exclusively localized at excitatory synapses in neurons.

Alternate Names/Synonyms: Postsynaptic Density Protein 95; Disks Large Homolog 4; Synapse-associated Protein 90; SAP-90

Product Type: Recombinant Antibody

Clone: RM288

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the N-terminus of human PSD95.

Applications: IHC, WB

Species Crossreactivity: Human, Mouse

Specificity: This antibody reacts to human and mouse PSD95. It may also react to rat PSD95, as predicted by immunogen homology.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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