anti-PSMA (human), Rabbit Monoclonal (RM327)

Product description: PSMA (Prostate-specific Membrane Antigen) a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer.

Alternate Names/Synonyms: Prostate-specific Membrane Antigen

Product Type: Recombinant Antibody

Clone: RM327

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human PSMA (Prostate-specific membrane antigen).

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human PSMA (Prostate-specific membrane antigen).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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