anti-RIG-I, mAb (Alme-1) (Biotin)

Product description: RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

Alternate Names/Synonyms: RIG-1; Retinoic Acid-inducible Gene 1 Protein; DEAD-box Protein 58; Probable ATP-dependent RNA Helicase DDX58

Product Type: Monoclonal Antibody

Clone: Alme-1

Isotype: Mouse IgG1

Immunogen: Recombinant human RIG-I (aa 201-713).

Labels - Conjugates: Biotin

Applications: IHC, IP, WB

Species Crossreactivity: Human, Mouse

Specificity: Recognizes human and mouse RIG-I.

Endotoxin: <0.001EU/µg purified protein or <1EU/mg purified protein (LAL test; Lonza).

Concentration: 0.5mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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