anti-RNASEH2B (human), Rabbit Monoclonal (RM433)

Product description: RNASE H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. It also mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). A form of hyper-inflammatory Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon and negative serologic investigations for common prenatal infection.

Alternate Names/Synonyms: RNase H2 Subunit B; Ribonuclease H2 Subunit B; Aicardi-Goutieres Syndrome 2 Protein; AGS2; Deleted in Lymphocytic Leukemia 8

Product Type: Recombinant Antibody

Clone: RM433

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human RNASEH2B.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: RM433 reacts to human RNASEH2B.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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