anti-Sirtuin 6 (human), mAb (S6R82-2)

Product description: Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.

Alternate Names/Synonyms: SIRT6; NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6

Product Type: Monoclonal Antibody

Clone: S6R82-2

Isotype: Mouse IgG2bkappa

Immunogen: Recombinant human sirtuin 6.

Applications: ELISA, WB

Species Crossreactivity: Human

Specificity: Recognizes human sirtuin 6. Detects a band of ~47kDa by Western blot.

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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