anti-Smac/Diablo (human), Rabbit Monoclonal (RM271)

Product description: Smac/Diablo is a 21 kDa mammalian mitochondrial protein that functions as a regulatory component during apoptosis. Upon mitochondrial stress, Smac/Diablo is released from mitochondria and competes with caspases for binding of IAPs (inhibitor of apoptosis proteins). The interaction of Smac/Diablo with IAPs relieves the inhibitory effect of the IAPs on caspases. This interaction involves mainly the amino-terminal residues of Smac/Diablo with the BIR3 region of XIAP, supplemented with several other hydrophobic interactions between the helical structures of Smac/Diablo and other areas of BIR3. Furthermore, Smac/DIABLO plays an important regulatory role in the sensitization of cancer cells to both immune-and drug-induced apoptosis. It promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway and acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).

Alternate Names/Synonyms: Direct IAP-binding Protein with low pI

Product Type: Recombinant Antibody

Clone: RM271

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human Smac (Diablo homolog, mitochondrial).

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human Smac (Diablo homolog, mitochondrial).

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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