anti-Stathmin (human), Rabbit Monoclonal (RM350)

Product description: Stathmin belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. Stathmin regulates microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers. Upon entry into mitosis, microtubules polymerize to form the mitotic spindle, a cellular structure that is essential for accurate chromosome segregation and cell division. The microtubule-depolymerizing activity of stathmin is switched off at the onset of mitosis by phosphorylation to allow microtubule polymerization and assembly of the mitotic spindle. Phosphorylated stathmin has to be reactivated by dephosphorylation before cells exit mitosis and enter a new interphase. Stathmin is critically important for the formation of a normal mitotic spindle upon entry into mitosis and also for the regulation of the function of the mitotic spindle in the later stages of mitosis and for the timely exit from mitosis.

Alternate Names/Synonyms: STMN1

Product Type: Recombinant Antibody

Clone: RM350

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the C-terminus of human Stathmin.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human Stathmin. It may also react to mouse or rat Stathmin, as predicted by immunogen homology.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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