anti-Surfactant protein B (human), Rabbit Monoclonal (RM370)

Product description: Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventilation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.

Alternate Names/Synonyms: SP-B; Pulmonary Surfactant-Associated Protein B

Product Type: Recombinant Antibody

Clone: RM370

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues near C-terminus of human SP-B (Surfactant protein B).

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human SP-B (Surfactant protein B) and proSP-B.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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