anti-SV2A, Rabbit Monoclonal (RM520)

Product description: SV2A (Synaptic Vesicle protein 2A) is an integral membrane glycoprotein present in synaptic vesicles. SV2s have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2A, SV2B and SV2C. SV2A is expressed ubiquitously throughout the brain. SV2B has a more restricted distribution with varying degrees of coexpression with SV2A. SV2C is more closely related to SV2A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2A is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium-stimulated exocytosis. SV2A is a highly glycosylated synaptic vesicle protein with homology to transmembrane transporters. This protein plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.

Alternate Names/Synonyms: Synaptic Vesicle Glycoprotein 2A

Product Type: Recombinant Antibody

Clone: RM520

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to the N-terminus of human SV2A.

Applications: IHC, WB

Species Crossreactivity: Human, Mouse, Rat

Specificity: This antibody reacts to human, mouse and rat SV2A (Synaptic vesicle glycoprotein 2A).

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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