anti-Syntaxin-1A (human), Rabbit Monoclonal (RM367)

Product description: Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxin-1A (Neuron-specific antigen HPC-1) belongs to the Q-SNARE protein family that participates in exocytosis. Syntaxin-1A is a t-SNARE abundantly expressed in most neurons and localized on the neuronal plasma membrane, where it participates in the formation of the trans-SNARE complex by engaging t-SNARE SNAP25 (synaptosomal-associated protein 25) and v-SNARE synaptobrevin (a.k.a. vesicle-associated membrane protein2 or VAMP2) to allow fusion between the synaptic vesicle and plasma membrane. Two types of syntaxin 1 isoforms exist. Syntaxin-1A is a key protein in ion channel regulation and synaptic exocytosis.

Alternate Names/Synonyms: Neuron-specific Antigen HPC-1

Product Type: Recombinant Antibody

Clone: RM367

Isotype: Rabbit IgG

Immunogen: A peptide corresponding to residues near N-terminus of human Syntaxin-1A.

Applications: IHC, WB

Species Crossreactivity: Human

Specificity: This antibody reacts to human, mouse, and rat Syntaxin-1A.

Concentration: N/A

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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