anti-TNF-alpha (mouse), mAb (blocking) (V1q) (preservative free)

Product description: Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and metabolism and is a member of a group of cytokines that stimulate the acute phase reaction. It causes tumor necrosis in vivo and shows also cytolytic activity against tumors. Signal transduction occurs via two types of TNF-receptors, the TNF-receptors 1 and 2. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha. The monoclonal antibody V1q recognizes endogenous mouse TNF-alpha.

Alternate Names/Synonyms: Tumor Necrosis Factor Ligand Superfamily Member 2; TNFSF2; Cachectin

Product Type: Monoclonal Antibody

Clone: V1q

Isotype: Rat IgG

Immunogen: Cytotoxin purified from ConA induced T cell clone 29.

Labels - Conjugates: Preservative Free

Applications: FACS, FUNC (Blocking)

Species Crossreactivity: Mouse, (Human)

Specificity: Recognizes mouse TNF-alpha. Reacts with both natural and recombinant mouse TNF-alpha. Cross-reacts with recombinant human TNF-alpha in an ELISA-binding assay (blocking not tested). Does not cross-react with TNF-beta (Lymphotoxin-alpha).

Concentration: 1mg/ml

Short Term Storage: +4°C

Long Term Storage: -20°C

Shipping: BLUE ICE

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

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